Nov. 27th, 2015 07:29 pm
Elemental Mercury Embolism to the Lung
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Francisco Gutiérrez, M.D., and Lucio Leon, M.D.
N Engl J Med 2000; 342:1791June 15, 2000DOI: 10.1056/NEJM200006153422405
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Figure 1 A 21-year-old dental assistant attempted suicide by injecting 10 ml (135 g) of elemental mercury (quicksilver) intravenously. She presented to the emergency room with tachypnea, a dry cough, and bloody sputum. While breathing room air, she had a partial pressure of oxygen of 86 mm Hg. A chest radiograph showed that the mercury was distributed in the lungs in a vascular pattern that was more pronounced at the bases. The patient was discharged after one week, with improvement in her pulmonary symptoms. Oral chelation therapy with dimercaprol was given for nine months, until the patient stopped the treatment; the urinary mercury level did not change during this period. At follow-up at 10 months, she was healthy, with none of the renal, gastrointestinal, or neurologic effects that can result from the oxidation of mercury in the blood and consequent exposure of these organ systems. The abnormalities on the chest radiograph were still apparent. Although these abnormalities are striking, the absence of clinical toxicity in this patient illustrates the differences in the acute and chronic effects of exposure to elemental mercury, inorganic mercury (e.g., mercuric chloride), and organic mercury (e.g., dimethylmercury). Inorganic and organic mercury are much more toxic than elemental mercury; for example, a dose of 400 mg of mercury in the form of dimethylmercury is usually lethal.
Francisco Gutiérrez, M.D.
Lucio Leon, M.D.
Hospital Sótero Del Rio, Santiago, Chile

N Engl J Med 2000; 342:1791June 15, 2000DOI: 10.1056/NEJM200006153422405
Share:
Slide
ArticleCiting Articles (6)

Figure 1 A 21-year-old dental assistant attempted suicide by injecting 10 ml (135 g) of elemental mercury (quicksilver) intravenously. She presented to the emergency room with tachypnea, a dry cough, and bloody sputum. While breathing room air, she had a partial pressure of oxygen of 86 mm Hg. A chest radiograph showed that the mercury was distributed in the lungs in a vascular pattern that was more pronounced at the bases. The patient was discharged after one week, with improvement in her pulmonary symptoms. Oral chelation therapy with dimercaprol was given for nine months, until the patient stopped the treatment; the urinary mercury level did not change during this period. At follow-up at 10 months, she was healthy, with none of the renal, gastrointestinal, or neurologic effects that can result from the oxidation of mercury in the blood and consequent exposure of these organ systems. The abnormalities on the chest radiograph were still apparent. Although these abnormalities are striking, the absence of clinical toxicity in this patient illustrates the differences in the acute and chronic effects of exposure to elemental mercury, inorganic mercury (e.g., mercuric chloride), and organic mercury (e.g., dimethylmercury). Inorganic and organic mercury are much more toxic than elemental mercury; for example, a dose of 400 mg of mercury in the form of dimethylmercury is usually lethal.
Francisco Gutiérrez, M.D.
Lucio Leon, M.D.
Hospital Sótero Del Rio, Santiago, Chile

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no subject
Argentum - Hydrargyrum?
В данном случае речь идет о ртути. Хотя и та оказалась почти совершенно не токсичной.
Вот что лично для меня совершенно неожиданно.
Re: Argentum - Hydrargyrum?
no subject
Относительно токсичности - наверное, более чем чистые металлы, токсичны их соли.
А ртутью ведь еще и сифилис пользовали. Даже результаты были неплохие. В эру до антибиотиков.
no subject
no subject
Дарвина не дали, потому что ртуть в жилу оказалась почти безвредной.
Развенчан еще один миф.
Теперь из меню психиатра можно вычеркнуть кучу меркурьевских фобий.
no subject
no subject
сразу вспоминается Депардье в роли врача-злодея у Блие в "Спасибо, жизнь!"))